Tubulin-Binding Agents

Tubulin-Binding Agents

Author: Teresa Carlomagno

Publisher: Springer

ISBN: 9783540690399

Category: Science

Page: 331

View: 937

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
Tubulin-Binding Agents
Language: en
Pages: 331
Authors: Teresa Carlomagno
Categories: Science
Type: BOOK - Published: 2009-05-28 - Publisher: Springer

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a
Some Effects of Tubulin-Binding Agents on Behaviour
Language: en
Pages: 228
Authors: G. Clingbine
Categories: Science
Type: BOOK - Published: 1978 - Publisher:

Books about Some Effects of Tubulin-Binding Agents on Behaviour
Tubulin-Binding Agents
Language: en
Pages: 331
Authors: Teresa Carlomagno, Karl-Heinz Altmann
Categories: Medical
Type: BOOK - Published: 2009-06-26 - Publisher: Springer Science & Business Media

This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts.
Evaluation of Tubulin Binding Agents Alone in Combination for the Treatment of Melanoma and Other Solid Cancers
Language: en
Pages: 225
Authors: Ashraf Sa Ta Azzabi, University of Newcastle upon Tyne. School of Clinical and Laboratory Sciences
Categories: Medical
Type: BOOK - Published: 2007 - Publisher:

Books about Evaluation of Tubulin Binding Agents Alone in Combination for the Treatment of Melanoma and Other Solid Cancers
The Pursuit of Tubulin-binding Agents
Language: en
Pages: 284
Authors: Vicki Chang
Categories: Chemistry, Organic
Type: BOOK - Published: 2012 - Publisher:

Presented here are two bodies of work regarding the synthesis of molecules related to tubulin-binding agents. Described in Chapter 1 is the synthesis of a library of biosynthetically-inspired colchicine-related compounds and the data regarding their biological activity. This chapter discusses using a pair of oxidative coupling reagents to generate molecular