Mechanisms of DNA Damage and Repair

Mechanisms of DNA Damage and Repair

Author: Michael G. Simic

Publisher: Springer Science & Business Media

ISBN: 9781461594628

Category: Science

Page: 578

View: 613

This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.
Mechanisms of DNA Damage and Repair
Language: en
Pages: 578
Authors: Michael G. Simic, Lawrence Grossman, Arthur C. Upton, David S. Bergtold
Categories: Science
Type: BOOK - Published: 2013-11-21 - Publisher: Springer Science & Business Media

This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level;
DNA Damage and Repair
Language: en
Pages: 639
Authors: Jac A. Nickoloff, Merl F. Hoekstra
Categories: Science
Type: BOOK - Published: 1998-08-12 - Publisher: Springer Science & Business Media

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention.
Mechanisms of DNA Repair
Language: en
Pages: 336
Authors: Jac A. Nickoloff, Merl F. Hoekstra
Categories: Science
Type: BOOK - Published: 2012-10-22 - Publisher: Academic Press

Written by research experts, this volume of Progress in Molecular Biology and Translational Science focuses on current science surrounding the mechanisms of DNA repair. Contributions from leading authorities Informs and updates on all the latest developments in the field
Mechanisms of DNA Damage and Repair
Language: en
Pages: 596
Authors: Michael G. Simic, Lawrence Grossman, Arthur C. Upton
Categories: Science
Type: BOOK - Published: 2014-09-01 - Publisher:

Books about Mechanisms of DNA Damage and Repair
DNA Repair and Replication
Language: en
Pages: 368
Authors: Roger J. A. Grand, John J. Reynolds
Categories: Science
Type: BOOK - Published: 2018-09-03 - Publisher: Garland Science

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and