Endothelin Receptors

Endothelin Receptors

Author: Robert R. Ruffolo, Jr.

Publisher: CRC Press

ISBN: 0849359384

Category: Science

Page: 302

View: 923

Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.
Endothelin Receptors
Language: en
Pages: 302
Authors: Robert R. Ruffolo, Jr.
Categories: Science
Type: BOOK - Published: 1995-05-19 - Publisher: CRC Press

Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to
Endothelin Receptors and Signaling Mechanisms
Language: en
Pages: 225
Authors: David M. Pollock, Robert F. Highsmith
Categories: Science
Type: BOOK - Published: 2013-03-09 - Publisher: Springer Science & Business Media

This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function.
Drug Discovery and Evaluation
Language: en
Pages: 759
Authors: Hans G. Vogel, Wolfgang H. Vogel
Categories: Medical
Type: BOOK - Published: 2013-04-17 - Publisher: Springer Science & Business Media

This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of
Endothelin and Its Inhibitors
Language: en
Pages: 560
Authors: Timothy D. Warner
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors
Peptidergic G Protein-coupled Receptors
Language: en
Pages: 225
Authors: North Atlantic Treaty Organization. Scientific Affairs Division
Categories: Science
Type: BOOK - Published: 1999 - Publisher: IOS Press

Peptides are a rapidly growing class of mediators whose activity regulates homeostasis as well as pathological processes. Most of the peptide-activated receptors belong to the superfamily of 7 transmembrane domain receptors coupled to G proteins. Peptides of different sizes (from a few to more than 100 aminoacids) activate peptidergic receptors